Human Tissue Models

PRODUCT / Human Tissue Models

Human Tissue Models(OECD Toxicity test standard model)

Produced from three-dimensional (3D) culturing cells-derived human tissue using tissue engineering technology, human tissue models are in vitro 3D organs structurally and functionally similar to the actual human tissue.
Human tissue models can be utilized for evaluation of toxicity and efficacy of therapeutics.

Biosolution's corneal epithelium model is registered as an international standard model in the OECD toxicity test guideline (OECD TG 492)

Skin
Model
  • Epidermis Model
  • Pigmented Epidermis Model
  • Full Thickness Skin Model
Mucosal
Model
  • Corneal Model
  • Oral Mucosa Model
  • Airway Epithelial Model
Spheroid
Model
  • Liver Model
  • Islet Model
  • Neuronal Model

Human tissue models reconstruct micro-organs at the micrometer level on the basis of the 3D-culture technologies and are highly similar to the human tissue in terms of its histological, morphological and biochemical characteristics.

Biosolution’s skin model consists of four major layers called the stratum corneum, granular layer, stratum spinosum and basal layer, which are all expressed in the human skin. The skin model can be utilized for the evaluation of toxicity (skin irritation, skin sensitization, genotoxicity, phototoxicity etc.) and efficacy (skin permeation, skin barrier function, moisturizing, anti-aging, whitening etc.) of skin therapeutics and cosmeceutics.



The cornea model is used to develop ophthalmic therapeutics as an alternative to animal testing; it can be utilized for evaluation of toxicity and efficacy of ophthalmic therapeutics. Experimental results using our cornea model have been published in internationally accredited academic journals.

References

  • The epithelial zinc transporter ZIP10 epigenetically regulates human epidermal homeostasis by modulation histone acetyltransferase activity. (Br. J. Dermatol. 2019)
  • Me-too validation study for in vitro eye irritation test with 3D-reconstructed human cornea epithelium, MCTT HCETM.(Toxicol. In Vitro. 2019)
  • Development and validation of UPLC method for WST-1 cell viability assay and its application to MCTT HCE™ eye irritation test for colorful substances, (Toxicol. in Vitro, 2019)
  • Nervonoylceramide (C24:1Cer), a lipid biomarker for ocular irritants released from the 3D reconstructed human cornea-like epithelium, MCTT HCE™ .(Toxicol. In Vitro. 2018)
  • Investigation of dermal toxicity of ionic liquids in monolayer-cultured skin cells and 3D reconstructed human skin models. (Toxicol. in Vitro, 2018)
  • Prevalidation trial for a novel in vitro eye irritation test using the reconstructed human cornea-like epithelial model, MCTT HCE™.(Toxicol. In Vitro. 2017)
  • Establishment of immortalized primary human keratinocytes and their application to toxicity assessment and three-dimensional skin culture construction. (Biomol. Ther. 2017)
  • PAL‑12, a new anti‑aging hexa‑peptoid, inhibits UVB‑induced photo-aging in human dermal fibroblasts and 3D reconstructed human full skin model, Keraskin‑FT™. (Arch Dermatol Res. 2017)
  • An Acrodermatitis Enteropathica-Associated Zn Transporter, ZIP4, Regulates Human Epidermal Homeostasis. (J. Invest. Dermatol. 2017)
  • Requirement of zinc transporter ZIP10 for epidermal development: Implication of the ZIP10–p63 axis in epithelial homeostasis. (PNAS, 2017)
  • Anti-Pigmentary Effect of (-)-4-Hydroxysattabacin from the Marine-Derived Bacterium Bacillus sp.(Mar. Drugs. 2017)
  • Exploration and comparison of in vitro eye irritation tests with the ISO standard in vivo rabbit test for the evaluation of the ocular irritancy of contact lenses. (Toxicol. In Vitro. 2016)
  • Evaluating the Micronucleus Induction Potential for the Genotoxicity Assay Using the Human Skin Model, KeraSkinTM. (J. Soc. Cosmet. Sci. Korea. 2016)
  • Identification of cornifelin and early growth response‑1 gene as novel biomarkers for in vitro eye irritation using a 3D reconstructed human cornea model MCTT HCE™ (Arch Toxicol, 2015)
  • KeraSkin™-VM: A novel reconstructed human epidermis model for skin irritation tests. (Toxicol. in Vitro, 2014)
  • Skin corrosion and irritation test of sunscreen nanoparticles using reconstructed 3D human skin model (Evir. Health. Toxicol. 2014)