人体组织模型

PRODUCT / 人体组织模型

人体组织模型(OECD-毒性评价标准模型)

所谓人体组织模型是基于人体组织工程学技术,应用人体来源的细胞,在体外重新构建与实际人体组织类似的3D组织模型。 人体组织模型主要用于药物毒性及有效性评价。

(株)BIOSOLUTION的眼角膜模型已被OECD毒性评价指南(OECD TG 492) 收录为国际标准模型

皮肤模型
  • 表皮模型
  • 色素化表皮模型
  • 皮肤全层模型
粘膜模型
  • 眼角膜模型
  • 口腔粘膜模型
  • 支气管粘膜模型
球体(Spheroid)模型
  • 肝脏球体(Spheroid)模型
  • 胰脏球体(Spheroid)模型
  • 神经球体(Spheroid)模型

人体组织模型是基于人体来源细胞的3D培养技术,在体外重新构
建微米单位的组织模型,并且其组织工程学、形态学、生化特
性几乎与实际人体组织十分接近。

人体皮肤组织模型具有与实际人体皮肤组织相同的4个皮肤分化层,并且具有功能性的角质层,于是可以进行皮肤刺激性、致敏性、遗传毒性、光毒性等人体毒性评价以及在细胞实验中无法涉及的皮肤渗透、皮肤屏障能、保湿、抗衰老、美白等功效评价



眼角膜模型可以替代家兔眼刺激实验(Draize Test),用于眼角膜刺激性评价。并且可以应用于眼科医疗器械的毒性评价、角膜渗透、眼药制剂的毒性评价以及药物有效性评价。
我司眼角膜模型的毒性评价研究结果以刊载于多数国际公认的学术杂志.

References

  • The epithelial zinc transporter ZIP10 epigenetically regulates human epidermal homeostasis by modulation histone acetyltransferase activity. (Br. J. Dermatol. 2019)
  • Me-too validation study for in vitro eye irritation test with 3D-reconstructed human cornea epithelium, MCTT HCETM.(Toxicol. In Vitro. 2019)
  • Development and validation of UPLC method for WST-1 cell viability assay and its application to MCTT HCE™ eye irritation test for colorful substances, (Toxicol. in Vitro, 2019)
  • Nervonoylceramide (C24:1Cer), a lipid biomarker for ocular irritants released from the 3D reconstructed human cornea-like epithelium, MCTT HCE™ .(Toxicol. In Vitro. 2018)
  • Investigation of dermal toxicity of ionic liquids in monolayer-cultured skin cells and 3D reconstructed human skin models. (Toxicol. in Vitro, 2018)
  • Prevalidation trial for a novel in vitro eye irritation test using the reconstructed human cornea-like epithelial model, MCTT HCE™.(Toxicol. In Vitro. 2017)
  • Establishment of immortalized primary human keratinocytes and their application to toxicity assessment and three-dimensional skin culture construction. (Biomol. Ther. 2017)
  • PAL‑12, a new anti‑aging hexa‑peptoid, inhibits UVB‑induced photo-aging in human dermal fibroblasts and 3D reconstructed human full skin model, Keraskin‑FT™. (Arch Dermatol Res. 2017)
  • An Acrodermatitis Enteropathica-Associated Zn Transporter, ZIP4, Regulates Human Epidermal Homeostasis. (J. Invest. Dermatol. 2017)
  • Requirement of zinc transporter ZIP10 for epidermal development: Implication of the ZIP10–p63 axis in epithelial homeostasis. (PNAS, 2017)
  • Anti-Pigmentary Effect of (-)-4-Hydroxysattabacin from the Marine-Derived Bacterium Bacillus sp.(Mar. Drugs. 2017)
  • Exploration and comparison of in vitro eye irritation tests with the ISO standard in vivo rabbit test for the evaluation of the ocular irritancy of contact lenses. (Toxicol. In Vitro. 2016)
  • Evaluating the Micronucleus Induction Potential for the Genotoxicity Assay Using the Human Skin Model, KeraSkinTM. (J. Soc. Cosmet. Sci. Korea. 2016)
  • Identification of cornifelin and early growth response‑1 gene as novel biomarkers for in vitro eye irritation using a 3D reconstructed human cornea model MCTT HCE™ (Arch Toxicol, 2015)
  • KeraSkin™-VM: A novel reconstructed human epidermis model for skin irritation tests. (Toxicol. in Vitro, 2014)
  • Skin corrosion and irritation test of sunscreen nanoparticles using reconstructed 3D human skin model (Evir. Health. Toxicol. 2014)